Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies

Protein aggregation is a hallmark of major neurodegenerative disorders. Increasing data suggest that smaller aggregates cause higher toxic response than filamentous aggregates (fibrils). However, the size of small aggregates has challenged their detection within biologically relevant environments. H...

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Detalles Bibliográficos
Autores principales: Morten, Michael J., Sirvio, Liina, Rupawala, Huzefa, Mee Hayes, Emma, Franco, Aitor, Radulescu, Carola, Ying, Liming, Barnes, Samuel J., Muga, Arturo, Ye, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573094/
https://www.ncbi.nlm.nih.gov/pubmed/36206368
http://dx.doi.org/10.1073/pnas.2205591119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573094/
https://www.ncbi.nlm.nih.gov/pubmed/36206368
http://dx.doi.org/10.1073/pnas.2205591119

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