Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation

Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral bioavailability (≈15%). The objective of this study was to develop bilosome-based mucoadhesive buccal sponge for augmenting the oral bioavailability of VDF. VDF-loaded bilosomes were fabricated and optimized usi...

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Detalles Bibliográficos
Autores principales: Aldawsari, Mohammed F., Khafagy, El-Sayed, Alotaibi, Hadil Faris, Abu Lila, Amr Selim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573218/
https://www.ncbi.nlm.nih.gov/pubmed/36236132
http://dx.doi.org/10.3390/polym14194184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573218/
https://www.ncbi.nlm.nih.gov/pubmed/36236132
http://dx.doi.org/10.3390/polym14194184

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