Cargando…

Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation

Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral bioavailability (≈15%). The objective of this study was to develop bilosome-based mucoadhesive buccal sponge for augmenting the oral bioavailability of VDF. VDF-loaded bilosomes were fabricated and optimized usi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aldawsari, Mohammed F., Khafagy, El-Sayed, Alotaibi, Hadil Faris, Abu Lila, Amr Selim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573218/ https://www.ncbi.nlm.nih.gov/pubmed/36236132 http://dx.doi.org/10.3390/polym14194184

Ejemplares similares

Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery
por: Khafagy, El-Sayed, et al.
Publicado: (2022)

Ocular Delivery of Bimatoprost-Loaded Solid Lipid Nanoparticles for Effective Management of Glaucoma
por: Satyanarayana, Sandeep Divate, et al.
Publicado: (2023)

In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives
por: Abu Lila, Amr Selim, et al.
Publicado: (2023)

Formulation optimization, in vitro and in vivo evaluation of niosomal nanocarriers for enhanced topical delivery of cetirizine
por: Aldawsari, Mohammed F., et al.
Publicado: (2023)

Ophthalmic Bimatoprost-Loaded Niosomal In Situ Gel: Preparation, Optimization, and In Vivo Pharmacodynamics Study
por: Aldawsari, Mohammed F., et al.
Publicado: (2023)

Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of Silymarin
por: Shriram, Ravi Gundadka, et al.
Publicado: (2022)

Biosynthesis of Silver Nanoparticles Using Commiphora mukul Extract: Evaluation of Anti-Arthritic Activity in Adjuvant-Induced Arthritis Rat Model
por: Singh, Anupama, et al.
Publicado: (2022)

Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis
por: Gopalakrishna, Poornima K., et al.
Publicado: (2023)

Mucoadhesive Interpolyelectrolyte Complexes for the Buccal Delivery of Clobetasol
por: Garipova, Venera R., et al.
Publicado: (2018)

Pulmonary Targeting of Levofloxacin Using Microsphere-Based Dry Powder Inhalation
por: Al Hagbani, Turki, et al.
Publicado: (2022)

Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis
por: Abruzzo, Angela, et al.
Publicado: (2020)

Development of Thermosensitive and Mucoadhesive Hydrogel for Buccal Delivery of (S)-Ketamine
por: Thouvenin, Agathe, et al.
Publicado: (2022)

Poly ε-Caprolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model
por: Singh, Ekta, et al.
Publicado: (2022)

Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation
por: Khafagy, El-Sayed, et al.
Publicado: (2023)

A clinical perspective on mucoadhesive buccal drug delivery systems
por: Gilhotra, Ritu M, et al.
Publicado: (2014)

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation
por: Zaman, Muhammad, et al.
Publicado: (2018)

Effect of permeation enhancers in the mucoadhesive buccal patches of salbutamol sulphate for unidirectional buccal drug delivery
por: Prasanth, V.V., et al.
Publicado: (2014)

Buccal administration of mucoadhesive blend films saturated with propranolol loaded nanoparticles
por: Kraisit, Pakorn, et al.
Publicado: (2018)

Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells
por: Youness, Rana Ahmed, et al.
Publicado: (2023)

Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model
por: Nair, Anroop B., et al.
Publicado: (2020)

Synthesis of Methacryloylated Hydroxyethylcellulose and Development of Mucoadhesive Wafers for Buccal Drug Delivery
por: Buang, Fhataheya, et al.
Publicado: (2022)

Gold Nanoparticle-Based Resuscitation of Cefoxitin against Clinical Pathogens: A Nano-Antibiotic Strategy to Overcome Resistance
por: Alafnan, Ahmed, et al.
Publicado: (2022)

Enhanced Cytotoxic Activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells
por: Al Saqr, Ahmed, et al.
Publicado: (2021)

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation
por: Nair, Anroop B., et al.
Publicado: (2021)

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization
por: Syed, Muhammad Ali, et al.
Publicado: (2022)

Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics
por: Gavin, Amy, et al.
Publicado: (2015)

Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide
por: Semalty, Mona, et al.
Publicado: (2008)

Mucoadhesive buccal films of glibenclamide: Development and evaluation
por: Muzib, Y Indira, et al.
Publicado: (2011)

Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac
por: Koirala, Santosh, et al.
Publicado: (2021)

Exorbitant Drug Loading of Metformin and Sitagliptin in Mucoadhesive Buccal Tablet: In Vitro and In Vivo Characterization in Healthy Volunteers
por: Shakir, Rouheena, et al.
Publicado: (2022)

In Vitro and In Vivo Characterisation of a Mucoadhesive Buccal Film Loaded with Doxycycline Hyclate for Topical Application in Periodontitis
por: Dinte, Elena, et al.
Publicado: (2023)

Bioactive Apigenin loaded oral nano bilosomes: Formulation optimization to preclinical assessment
por: Zafar, Ameeduzzafar, et al.
Publicado: (2021)

Bilosomes as Nanoplatform for Oral Delivery and Modulated In Vivo Antimicrobial Activity of Lycopene
por: Binsuwaidan, Reem, et al.
Publicado: (2022)

Screening of Apoptosis Pathway-Mediated Anti-Proliferative Activity of the Phytochemical Compound Furanodienone against Human Non-Small Lung Cancer A-549 Cells
por: Al Saqr, Ahmed, et al.
Publicado: (2022)

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties
por: Jovanović, Marija, et al.
Publicado: (2021)

Thermosensitive and Mucoadhesive Sol-Gel Composites of Paclitaxel/Dimethyl-β-Cyclodextrin for Buccal Delivery
por: Choi, Soon Gil, et al.
Publicado: (2014)

Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation
por: Ahmed, Sadek, et al.
Publicado: (2020)

Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers
por: Ahmed, Tarek A, et al.
Publicado: (2020)

Formulation and Evaluation of Mucoadhesive Buccal Films of Enalapril Maleate
por: Semalty, A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_dkekqggvugrfsjjh40j2dfsvvc