Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities

Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant antimetabolites of folic acid, which are Methotre...

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Autores principales: Kovalev, Igor S., Zyryanov, Grigory V., Santra, Sougata, Majee, Adinath, Varaksin, Mikhail V., Charushin, Valery N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573478/
https://www.ncbi.nlm.nih.gov/pubmed/36234766
http://dx.doi.org/10.3390/molecules27196229
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author Kovalev, Igor S.
Zyryanov, Grigory V.
Santra, Sougata
Majee, Adinath
Varaksin, Mikhail V.
Charushin, Valery N.
author_facet Kovalev, Igor S.
Zyryanov, Grigory V.
Santra, Sougata
Majee, Adinath
Varaksin, Mikhail V.
Charushin, Valery N.
author_sort Kovalev, Igor S.
collection PubMed
description Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant antimetabolites of folic acid, which are Methotrexate (MTX), Raltitrexed (Tomudex, ZD1694), Pralatrexate, Pemetrexed, TNP-351, and Lometrexol. In addition, the applications or uses of these folic acid antimetabolites are also discussed.
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spelling pubmed-95734782022-10-17 Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities Kovalev, Igor S. Zyryanov, Grigory V. Santra, Sougata Majee, Adinath Varaksin, Mikhail V. Charushin, Valery N. Molecules Review Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant antimetabolites of folic acid, which are Methotrexate (MTX), Raltitrexed (Tomudex, ZD1694), Pralatrexate, Pemetrexed, TNP-351, and Lometrexol. In addition, the applications or uses of these folic acid antimetabolites are also discussed. MDPI 2022-09-22 /pmc/articles/PMC9573478/ /pubmed/36234766 http://dx.doi.org/10.3390/molecules27196229 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kovalev, Igor S.
Zyryanov, Grigory V.
Santra, Sougata
Majee, Adinath
Varaksin, Mikhail V.
Charushin, Valery N.
Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
title Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
title_full Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
title_fullStr Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
title_full_unstemmed Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
title_short Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
title_sort folic acid antimetabolites (antifolates): a brief review on synthetic strategies and application opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573478/
https://www.ncbi.nlm.nih.gov/pubmed/36234766
http://dx.doi.org/10.3390/molecules27196229
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