Cargando…

Structural Variations in the Central Heterocyclic Scaffold of Tripartite 2,6-Difluorobenzamides: Influence on Their Antibacterial Activity against MDR Staphylococcus aureus

Five series of heterocyclic tripartite 2,6-difluorobenzamides, namely 1,2,3-triazoles, 1,2,4- and 1,3,4-oxadiazoles, analogs of reported model anti-staphylococcal compounds, were prepared. The purpose was to investigate the influence of the nature of the heterocyclic central scaffold on the biologic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barbier, Thibaut, Badiou, Cédric, Davy, Floriane, Queneau, Yves, Dumitrescu, Oana, Lina, Gérard, Soulère, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573484/ https://www.ncbi.nlm.nih.gov/pubmed/36235156 http://dx.doi.org/10.3390/molecules27196619

Ejemplares similares

Importance of the 2,6-Difluorobenzamide Motif for FtsZ Allosteric Inhibition: Insights from Conformational Analysis, Molecular Docking and Structural Modifications
por: Barbier, Thibaut, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Benzo[b]thiophene Acylhydrazones as Antimicrobial Agents against Multidrug-Resistant Staphylococcus aureus
por: Barbier, Thibaut, et al.
Publicado: (2022)

Docking-based virtual screening studies aiming at the covalent inhibition of SARS-CoV-2 M(Pro) by targeting the cysteine 145
por: Soulère, Laurent, et al.
Publicado: (2021)

In Silico Identification of Potential Inhibitors of the SARS-CoV-2 Main Protease among a PubChem Database of Avian Infectious Bronchitis Virus 3CLPro Inhibitors
por: Soulère, Laurent, et al.
Publicado: (2023)

N-(4-Cyanophenyl)-2,6-difluorobenzamide
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

2-Substituted Aniline as a Simple Scaffold for LuxR-Regulated QS Modulation
por: Li, Sizhe, et al.
Publicado: (2017)

Heterocyclic Chemistry Applied to the Design of N-Acyl Homoserine Lactone Analogues as Bacterial Quorum Sensing Signals Mimics
por: Zhang, Qiang, et al.
Publicado: (2021)

N,N′-[4,4′-Methylenebis(4,1-phenylene)]bis(2,6-difluorobenzamide)
por: Al-Dajani, Mohammad T. M., et al.
Publicado: (2011)

Antimicrobial Action and Reversal of Resistance in MRSA by Difluorobenzamide Derivatives Targeted at FtsZ
por: Chai, Wern Chern, et al.
Publicado: (2020)

Crystal structure of N-{4-[(6-chloropyridin-3-yl)methoxy]phenyl}-2,6-difluorobenzamide
por: Liang, Ying, et al.
Publicado: (2016)

Biological Evaluation and Docking Studies of New Carbamate, Thiocarbamate, and Hydrazide Analogues of Acyl Homoserine Lactones as Vibrio fischeri-Quorum Sensing Modulators
por: Zhang, Qiang, et al.
Publicado: (2020)

Towards More Practical Methods for the Chemical Synthesis of Thioamides Using Sulfuration Agents: A Decade Update
por: Zhang, Qiang, et al.
Publicado: (2023)

N-[3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2,6-difluorobenzamide
por: Liang, Ying, et al.
Publicado: (2010)

Synergistic Effects of Influenza and Staphylococcus aureus Toxins on Inflammation Activation and Cytotoxicity in Human Monocytic Cell Lines
por: Jeannoel, Marion, et al.
Publicado: (2018)

Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains
por: Hodille, Elisabeth, et al.
Publicado: (2018)

N-{N-[5-(2,4-Dichlorophenyl)-1,3,4-thiadiazol-2-yl]carbamoyl}-2,6-difluorobenzamide
por: Wang, Peng, et al.
Publicado: (2009)

N-(5-Chloro-1,3-thiazol-2-yl)-2,4-difluorobenzamide
por: Liu, Xi-Wang, et al.
Publicado: (2012)

Panton-Valentine Leukocidin Does Play a Role in the Early Stage of Staphylococcus aureus Skin Infections: A Rabbit Model
por: Lipinska, Urszula, et al.
Publicado: (2011)

Staphylococcal Panton–Valentine Leucocidin and Gamma Haemolysin Target and Lyse Mature Bone Marrow Leucocytes
por: Hodille, Elisabeth, et al.
Publicado: (2020)

N-{[2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]aminocarbonyl}-2,6-difluorobenzamide
por: Liu, Yin-hong, et al.
Publicado: (2008)

Esters of Glucose-2-Phosphate: Occurrence and Chemistry
por: Zhang, Qiang, et al.
Publicado: (2020)

Therapeutic potential of heterocyclic pyrimidine scaffolds
por: Kumar, Sanjiv, et al.
Publicado: (2018)

Tripartite Mentality
por: Searcy, J. T.
Publicado: (1905)

Seeking heterocyclic scaffolds as antivirals against dengue virus
por: De, Soumik, et al.
Publicado: (2022)

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
por: Panda, Siva S., et al.
Publicado: (2023)

A continuous spectrophotometric assay that distinguishes between phospholipase A(1) and A(2) activities
por: El Alaoui, Meddy, et al.
Publicado: (2016)

Synthesis and Regioselective Reaction of Some Unsymmetrical Heterocyclic Chalcone Derivatives and Spiro Heterocyclic Compounds as Antibacterial Agents
por: El-Hashash, Maher A., et al.
Publicado: (2015)

Insights into the Quorum Sensing Regulon of the Acidophilic Acidithiobacillus ferrooxidans Revealed by Transcriptomic in the Presence of an Acyl Homoserine Lactone Superagonist Analog
por: Mamani, Sigde, et al.
Publicado: (2016)

Tripartite motif containing 26 prevents steatohepatitis progression by suppressing C/EBPδ signalling activation
por: Xu, Minxuan, et al.
Publicado: (2023)

The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members
por: Mandell, Michael A., et al.
Publicado: (2020)

A Structurally Diverse Heterocyclic Library by Decoration of Oxcarbazepine Scaffold
por: Vaghi, Luca, et al.
Publicado: (2013)

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
por: Abdildinova, Aizhan, et al.
Publicado: (2021)

Recent biological applications of heterocyclic hybrids containing s-triazine scaffold
por: Ali, Muhammad Imran, et al.
Publicado: (2023)

Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach
por: VanDyke, Derek, et al.
Publicado: (2023)

Computationally Designed AMPs with Antibacterial and Antibiofilm Activity against MDR Acinetobacter baumannii
por: Alsaab, Fahad M., et al.
Publicado: (2023)

N,N′-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers
por: des Essarts, Yannick Raoul, et al.
Publicado: (2013)

Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents
por: Roussaki, Marina, et al.
Publicado: (2012)

Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
por: Tahlan, Sumit, et al.
Publicado: (2019)

In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents
por: Tahlan, Sumit, et al.
Publicado: (2019)

Chromene- and Quinoline-3-Carbaldehydes: Useful Intermediates in the Synthesis of Heterocyclic Scaffolds
por: Rocha, Djenisa H. A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_oq04lb7poiq7he250r7ennjch8