Cargando…
Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis
(1) Background: Colorectal cancer (CRC) is a common gastrointestinal malignancy, accounting for the second largest gastrointestinal tumor. MORC2, a newly discovered chromatin remodeling protein, plays an important role in the biological processes of various cancers. However, the potential mechanisti...
Autores principales: | Ou, Kepeng, Li, Youjian, Long, Yiling, Luo, Yafei, Tang, Dianyong, Chen, Zhongzhu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573567/ https://www.ncbi.nlm.nih.gov/pubmed/36234785 http://dx.doi.org/10.3390/molecules27196247 |
Ejemplares similares
-
By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer
por: Zhang, Qing, et al.
Publicado: (2015) -
The PPARγ‐SETD8 axis constitutes an epigenetic, p53‐independent checkpoint on p21‐mediated cellular senescence
por: Shih, Chieh‐Tien, et al.
Publicado: (2017) -
Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
por: Kim, Young Yeon, et al.
Publicado: (2017) -
Regulation of cellular senescence via the FOXO4‐p53 axis
por: Bourgeois, Benjamin, et al.
Publicado: (2018) -
Role of p53 in the Regulation of Cellular Senescence
por: Mijit, Mahmut, et al.
Publicado: (2020)