Synthesis and SAR Analysis of Novel 4-Hydroxytamoxifen Analogues Based on Their Cytotoxic Activity and Electron-Donor Character

Utilizing McMurry reactions of 4,4′-dihydroxybenzophenone with appropriate carbonyl compounds, a series of 4-Hydroxytamoxifen analogues were synthesized. Their cytotoxic activity was evaluated in vitro on four human malignant cell lines (MCF-7, MDA-MB 231, A2058, HT-29). It was found that some of th...

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Detalles Bibliográficos
Autores principales: Duró, Cintia, Jernei, Tamás, Szekeres, Krisztina J., Láng, Győző G., Oláh-Szabó, Rita, Bősze, Szilvia, Szabó, Ildikó, Hudecz, Ferenc, Csámpai, Antal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573586/
https://www.ncbi.nlm.nih.gov/pubmed/36235291
http://dx.doi.org/10.3390/molecules27196758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573586/
https://www.ncbi.nlm.nih.gov/pubmed/36235291
http://dx.doi.org/10.3390/molecules27196758

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