Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity

The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II diabetes. Therapeutic interventions targeting IAPP amyloidogenesis, which contributes to pancreatic β-cell degeneration,...

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Detalles Bibliográficos
Autores principales: Fortier, Mathilde, Côté-Cyr, Mélanie, Nguyen, Vy, Babych, Margaryta, Nguyen, Phuong Trang, Gaudreault, Roger, Bourgault, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573943/
https://www.ncbi.nlm.nih.gov/pubmed/36262476
http://dx.doi.org/10.3389/fmolb.2022.1017336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573943/
https://www.ncbi.nlm.nih.gov/pubmed/36262476
http://dx.doi.org/10.3389/fmolb.2022.1017336

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