The high toxicity of DSB-clusters modelling high-LET-DNA damage derives from inhibition of c-NHEJ and promotion of alt-EJ and SSA despite increases in HR

Heavy-ion radiotherapy utilizing high linear energy transfer (high-LET) ionizing radiation (IR) is a promising cancer treatment modality owing to advantageous physical properties of energy deposition and associated toxicity over X-rays. Therapies utilizing high-LET radiation will benefit from a bett...

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Detalles Bibliográficos
Autores principales: Mladenova, Veronika, Mladenov, Emil, Chaudhary, Shipra, Stuschke, Martin, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574094/
https://www.ncbi.nlm.nih.gov/pubmed/36263011
http://dx.doi.org/10.3389/fcell.2022.1016951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574094/
https://www.ncbi.nlm.nih.gov/pubmed/36263011
http://dx.doi.org/10.3389/fcell.2022.1016951

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