Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model

DNA-encoded delivery and in vivo expression of antibody therapeutics presents an innovative alternative to conventional protein production and administration, including for cancer treatment. To support clinical translation, we evaluated this approach in 18 40-45 kg sheep, using a clinical-matched in...

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Detalles Bibliográficos
Autores principales: Hollevoet, Kevin, Thomas, Debby, Compernolle, Griet, Vermeire, Giles, De Smidt, Elien, De Vleeschauwer, Stéphanie, Smith, Trevor R. F., Fisher, Paul D., Dewilde, Maarten, Geukens, Nick, Declerck, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574358/
https://www.ncbi.nlm.nih.gov/pubmed/36263202
http://dx.doi.org/10.3389/fonc.2022.1017612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574358/
https://www.ncbi.nlm.nih.gov/pubmed/36263202
http://dx.doi.org/10.3389/fonc.2022.1017612

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