Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis

Distinguishing oncogenic mutations from variants of unknown significance (VUS) is critical for precision cancer medicine. Here, computational modeling of 71,756 RET variants for positive selection together with functional assays of 110 representative variants identified a three-dimensional cluster o...

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Detalles Bibliográficos
Autores principales: Tabata, Junya, Nakaoku, Takashi, Araki, Mitsugu, Yoshino, Ryunosuke, Kohsaka, Shinji, Otsuka, Ayaka, Ikegami, Masachika, Ui, Ayako, Kanno, Shin-ichiro, Miyoshi, Keiko, Matsumoto, Shigeyuki, Sagae, Yukari, Yasui, Akira, Sekijima, Masakazu, Mano, Hiroyuki, Okuno, Yasushi, Okamoto, Aikou, Kohno, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574375/
https://www.ncbi.nlm.nih.gov/pubmed/36166639
http://dx.doi.org/10.1158/0008-5472.CAN-22-0834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574375/
https://www.ncbi.nlm.nih.gov/pubmed/36166639
http://dx.doi.org/10.1158/0008-5472.CAN-22-0834

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