New insights into P2X7 receptor regulation: Ca(2+)-calmodulin and GDP bind to the soluble P2X7 ballast domain

P2X7 receptors are nonselective cation channels that are activated by extracellular ATP and play important roles in inflammation. They differ from other P2X family members by a large intracellular C-terminus that mediates diverse signaling processes that are little understood. A recent cryo-EM study...

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Detalles Bibliográficos
Autores principales: Sander, Simon, Müller, Isabel, Garcia-Alai, Maria M., Nicke, Annette, Tidow, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574498/
https://www.ncbi.nlm.nih.gov/pubmed/36115462
http://dx.doi.org/10.1016/j.jbc.2022.102495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574498/
https://www.ncbi.nlm.nih.gov/pubmed/36115462
http://dx.doi.org/10.1016/j.jbc.2022.102495

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