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New insights into P2X7 receptor regulation: Ca(2+)-calmodulin and GDP bind to the soluble P2X7 ballast domain
P2X7 receptors are nonselective cation channels that are activated by extracellular ATP and play important roles in inflammation. They differ from other P2X family members by a large intracellular C-terminus that mediates diverse signaling processes that are little understood. A recent cryo-EM study...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574498/ https://www.ncbi.nlm.nih.gov/pubmed/36115462 http://dx.doi.org/10.1016/j.jbc.2022.102495 |