Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity

Human mono-ADP-ribosylating PARP enzymes have been linked to several clinically relevant processes and many of these PARPs have been suggested as potential drug targets. Despite recent advances in the field, efforts to discover inhibitors have been hindered by the lack of tools to rapidly screen for...

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Detalles Bibliográficos
Autores principales: Galera-Prat, Albert, Alaviuhkola, Juho, Alanen, Heli I, Lehtiö, Lari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574550/
https://www.ncbi.nlm.nih.gov/pubmed/36130221
http://dx.doi.org/10.1093/protein/gzac006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574550/
https://www.ncbi.nlm.nih.gov/pubmed/36130221
http://dx.doi.org/10.1093/protein/gzac006

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