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Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity
Human mono-ADP-ribosylating PARP enzymes have been linked to several clinically relevant processes and many of these PARPs have been suggested as potential drug targets. Despite recent advances in the field, efforts to discover inhibitors have been hindered by the lack of tools to rapidly screen for...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574550/ https://www.ncbi.nlm.nih.gov/pubmed/36130221 http://dx.doi.org/10.1093/protein/gzac006 |