Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies

Coproporphyrin I (CP‐I) is an endogenous biomarker supporting the prediction of drug–drug interactions (DDIs) involving hepatic organic anion transporting polypeptide 1B (OATP1B). We previously constructed a physiologically‐based pharmacokinetic (PBPK) model for CP‐I using clinical DDI data with an...

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Detalles Bibliográficos
Autores principales: Yoshikado, Takashi, Aoki, Yasunori, Mochizuki, Tatsuki, Rodrigues, A. David, Chiba, Koji, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574750/
https://www.ncbi.nlm.nih.gov/pubmed/35945914
http://dx.doi.org/10.1002/psp4.12849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574750/
https://www.ncbi.nlm.nih.gov/pubmed/35945914
http://dx.doi.org/10.1002/psp4.12849

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