The OTUD6B‐LIN28B‐MYC axis determines the proliferative state in multiple myeloma

Deubiquitylases (DUBs) are therapeutically amenable components of the ubiquitin machinery that stabilize substrate proteins. Their inhibition can destabilize oncoproteins that may otherwise be undruggable. Here, we screened for DUB vulnerabilities in multiple myeloma, an incurable malignancy with de...

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Detalles Bibliográficos
Autores principales: Paulmann, Carmen, Spallek, Ria, Karpiuk, Oleksandra, Heider, Michael, Schäffer, Isabell, Zecha, Jana, Klaeger, Susan, Walzik, Michaela, Öllinger, Rupert, Engleitner, Thomas, Wirth, Matthias, Keller, Ulrich, Krönke, Jan, Rudelius, Martina, Kossatz, Susanne, Rad, Roland, Kuster, Bernhard, Bassermann, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574752/
https://www.ncbi.nlm.nih.gov/pubmed/36059274
http://dx.doi.org/10.15252/embj.2022110871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574752/
https://www.ncbi.nlm.nih.gov/pubmed/36059274
http://dx.doi.org/10.15252/embj.2022110871

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