Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

[Image: see text] From a designed library of indolyl pyrimidinamines, we identified a highly potent and cell-active chemical probe (17) that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve). Comprehensive evaluation of inhibitor selectivity confirmed that this PIKfyve probe demonstrates...

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Detalles Bibliográficos
Autores principales: Drewry, David H., Potjewyd, Frances M., Bayati, Armin, Smith, Jeffery L., Dickmander, Rebekah J., Howell, Stefanie, Taft-Benz, Sharon, Min, Sophia M., Hossain, Mohammad Anwar, Heise, Mark, McPherson, Peter S., Moorman, Nathaniel J., Axtman, Alison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574855/
https://www.ncbi.nlm.nih.gov/pubmed/36111834
http://dx.doi.org/10.1021/acs.jmedchem.2c00697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574855/
https://www.ncbi.nlm.nih.gov/pubmed/36111834
http://dx.doi.org/10.1021/acs.jmedchem.2c00697

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