Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4

[Image: see text] Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors due to a dearth of E3-binding small molecules. We show that gen...

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Detalles Bibliográficos
Autores principales: Chana, Chetan K., Maisonneuve, Pierre, Posternak, Ganna, Grinberg, Nicolas G.A., Poirson, Juline, Ona, Samara M., Ceccarelli, Derek F., Mader, Pavel, St-Cyr, Daniel J., Pau, Victor, Kurinov, Igor, Tang, Xiaojing, Deng, Dongjing, Cui, Weiren, Su, Wenji, Kuai, Letian, Soll, Richard, Tyers, Mike, Röst, Hannes L., Batey, Robert A., Taipale, Mikko, Gingras, Anne-Claude, Sicheri, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574856/
https://www.ncbi.nlm.nih.gov/pubmed/36117290
http://dx.doi.org/10.1021/acs.jmedchem.2c00509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574856/
https://www.ncbi.nlm.nih.gov/pubmed/36117290
http://dx.doi.org/10.1021/acs.jmedchem.2c00509

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