Inhibitory synaptic loss drives network changes in multiple sclerosis: An ex vivo to in silico translational study

BACKGROUND: Synaptic and neuronal loss contribute to network dysfunction and disability in multiple sclerosis (MS). However, it is unknown whether excitatory or inhibitory synapses and neurons are more vulnerable and how their losses impact network functioning. OBJECTIVE: To quantify excitatory and...

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Detalles Bibliográficos
Autores principales: Huiskamp, Marijn, Kiljan, Svenja, Kulik, Shanna, Witte, Maarteen E, Jonkman, Laura E, GJM Bol, John, Schenk, Geert J, Hulst, Hanneke E, Tewarie, Prejaas, Schoonheim, Menno M, Geurts, Jeroen JG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574900/
https://www.ncbi.nlm.nih.gov/pubmed/36189828
http://dx.doi.org/10.1177/13524585221125381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574900/
https://www.ncbi.nlm.nih.gov/pubmed/36189828
http://dx.doi.org/10.1177/13524585221125381

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