Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease

[Image: see text] SARS-CoV-2 is the causative agent behind the COVID-19 pandemic. The main protease (M(pro), 3CL(pro)) of SARS-CoV-2 is a key enzyme that processes polyproteins translated from the viral RNA. M(pro) is therefore an attractive target for the design of inhibitors that block viral repli...

Descripción completa

Detalles Bibliográficos
Autores principales: Cooper, Mark S., Zhang, Linlin, Ibrahim, Mohamed, Zhang, Kaixuan, Sun, Xinyuanyuan, Röske, Judith, Göhl, Matthias, Brönstrup, Mark, Cowell, Justin K., Sauerhering, Lucie, Becker, Stephan, Vangeel, Laura, Jochmans, Dirk, Neyts, Johan, Rox, Katharina, Marsh, Graham P., Maple, Hannah J., Hilgenfeld, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574927/
https://www.ncbi.nlm.nih.gov/pubmed/36179320
http://dx.doi.org/10.1021/acs.jmedchem.2c01131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574927/
https://www.ncbi.nlm.nih.gov/pubmed/36179320
http://dx.doi.org/10.1021/acs.jmedchem.2c01131

Ejemplares similares