Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells

L‐type amino acid transporter 1 (LAT1; SLC7A5), which preferentially transports large neutral amino acids, is highly upregulated in various cancers. LAT1 supplies cancer cells with amino acids as substrates for enhanced biosynthetic and bioenergetic reactions and stimulates signalling networks invol...

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Detalles Bibliográficos
Autores principales: Nishikubo, Kou, Ohgaki, Ryuichi, Okanishi, Hiroki, Okuda, Suguru, Xu, Minhui, Endou, Hitoshi, Kanai, Yoshikatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575050/
https://www.ncbi.nlm.nih.gov/pubmed/36071551
http://dx.doi.org/10.1111/jcmm.17553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575050/
https://www.ncbi.nlm.nih.gov/pubmed/36071551
http://dx.doi.org/10.1111/jcmm.17553

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