CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin‐induced cardiotoxicity by regulating the IRE1α/XBP1s pathway

Doxorubicin (Dox), an anthracycline antibiotic with potent antitumor effects, has limited clinical applications due to cumulative cardiotoxicity. Ca(2+)/calmodulin‐dependent protein kinase II (CaMKII) is implicated in the pathological progression of Dox‐induced cardiotoxicity. This study examined th...

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Detalles Bibliográficos
Autores principales: Kong, Lingheng, Zhang, Yimeng, Ning, Jiayi, Xu, Chennian, Wang, Zhenyi, Yang, Jian, Yang, Lifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575131/
https://www.ncbi.nlm.nih.gov/pubmed/36111515
http://dx.doi.org/10.1111/jcmm.17560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575131/
https://www.ncbi.nlm.nih.gov/pubmed/36111515
http://dx.doi.org/10.1111/jcmm.17560

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