scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies

BACKGROUND: The rapid accumulation of single-cell RNA sequencing (scRNA-seq) data presents unique opportunities to decode the genetically mediated cell-type specificity in complex diseases. Here, we develop a new method, scGWAS, which effectively leverages scRNA-seq data to achieve two goals: (1) to...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Peilin, Hu, Ruifeng, Yan, Fangfang, Dai, Yulin, Zhao, Zhongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575201/
https://www.ncbi.nlm.nih.gov/pubmed/36253801
http://dx.doi.org/10.1186/s13059-022-02785-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575201/
https://www.ncbi.nlm.nih.gov/pubmed/36253801
http://dx.doi.org/10.1186/s13059-022-02785-w

Ejemplares similares