A quantitative metric of pioneer activity reveals that HNF4A has stronger in vivo pioneer activity than FOXA1

BACKGROUND: We and others have suggested that pioneer activity — a transcription factor’s (TF’s) ability to bind and open inaccessible loci — is not a qualitative trait limited to a select class of pioneer TFs. We hypothesize that most TFs display pioneering activity that depends on the TF concentra...

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Detalles Bibliográficos
Autores principales: Hansen, Jeffrey L., Cohen, Barak A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575205/
https://www.ncbi.nlm.nih.gov/pubmed/36253868
http://dx.doi.org/10.1186/s13059-022-02792-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575205/
https://www.ncbi.nlm.nih.gov/pubmed/36253868
http://dx.doi.org/10.1186/s13059-022-02792-x

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