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A quantitative metric of pioneer activity reveals that HNF4A has stronger in vivo pioneer activity than FOXA1
BACKGROUND: We and others have suggested that pioneer activity — a transcription factor’s (TF’s) ability to bind and open inaccessible loci — is not a qualitative trait limited to a select class of pioneer TFs. We hypothesize that most TFs display pioneering activity that depends on the TF concentra...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575205/ https://www.ncbi.nlm.nih.gov/pubmed/36253868 http://dx.doi.org/10.1186/s13059-022-02792-x |