Recovery of Conformational Continuum From Single-Particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth

This work is based on the manifold-embedding approach to study biological molecules exhibiting continuous conformational changes. Previous work established a method—now termed ManifoldEM—capable of reconstructing 3D movies and accompanying free-energy landscapes from single-particle cryo-EM images o...

Descripción completa

Detalles Bibliográficos
Autores principales: Seitz, Evan, Acosta-Reyes, Francisco, Maji, Suvrajit, Schwander, Peter, Frank, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575687/
https://www.ncbi.nlm.nih.gov/pubmed/36258699
http://dx.doi.org/10.1109/tci.2022.3174801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575687/
https://www.ncbi.nlm.nih.gov/pubmed/36258699
http://dx.doi.org/10.1109/tci.2022.3174801

Ejemplares similares