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Recovery of Conformational Continuum From Single-Particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth

This work is based on the manifold-embedding approach to study biological molecules exhibiting continuous conformational changes. Previous work established a method—now termed ManifoldEM—capable of reconstructing 3D movies and accompanying free-energy landscapes from single-particle cryo-EM images o...

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Detalles Bibliográficos
Autores principales:	Seitz, Evan, Acosta-Reyes, Francisco, Maji, Suvrajit, Schwander, Peter, Frank, Joachim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575687/ https://www.ncbi.nlm.nih.gov/pubmed/36258699 http://dx.doi.org/10.1109/tci.2022.3174801

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