Bmi1 suppresses protein synthesis and promotes proteostasis in hematopoietic stem cells

The polycomb complex component Bmi1 promotes the maintenance of stem cells in multiple postnatal tissues, partly by negatively regulating the expression of p16(Ink4a) and p19(Arf), tumor suppressors associated with cellular senescence. However, deficiency for p16(Ink4a) and p19(Arf) only partially r...

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Detalles Bibliográficos
Autores principales: Burgess, Rebecca J., Zhao, Zhiyu, Nakada, Daisuke, Morrison, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575696/
https://www.ncbi.nlm.nih.gov/pubmed/36167470
http://dx.doi.org/10.1101/gad.349917.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575696/
https://www.ncbi.nlm.nih.gov/pubmed/36167470
http://dx.doi.org/10.1101/gad.349917.122

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