Cargando…

Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries

BACKGROUND: Epidemiological studies observed gender differences in COVID-19 outcomes, however, whether sex hormone plays a causal in COVID-19 risk remains unclear. This study aimed to examine associations of sex hormone, sex hormones-binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xinxuan, Zhou, Yajing, Yuan, Shuai, Zhou, Xuan, Wang, Lijuan, Sun, Jing, Yu, Lili, Zhu, Jinghan, Zhang, Han, Yang, Nan, Dai, Shuhui, Song, Peige, Larsson, Susanna C, Theodoratou, Evropi, Zhu, Yimin, Li, Xue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Epidemiology and Global Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576268/ https://www.ncbi.nlm.nih.gov/pubmed/36250974 http://dx.doi.org/10.7554/eLife.79720

Ejemplares similares

Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation
por: Yuan, Shuai, et al.
Publicado: (2022)

Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis
por: Yuan, Shuai, et al.
Publicado: (2023)

A rapid review of COVID-19’s global impact on breast cancer screening participation rates and volumes from January to December 2020
por: Lee, Reagan, et al.
Publicado: (2023)

Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
por: Yuan, Shuai, et al.
Publicado: (2022)

Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study
por: Zhou, Xuan, et al.
Publicado: (2022)

A systematic review of microbial markers for risk prediction of colorectal neoplasia
por: Yu, Lili, et al.
Publicado: (2022)

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health
por: Davies, Neil Martin, et al.
Publicado: (2019)

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity
por: Carrasquilla, Germán D, et al.
Publicado: (2022)

Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
por: Yuan, Shuai, et al.
Publicado: (2023)

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation
por: Schooling, CM, et al.
Publicado: (2020)

Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study
por: Huang, Wuqing, et al.
Publicado: (2021)

Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study
por: Richardson, Tom G, et al.
Publicado: (2023)

Morning chronotype and digestive tract cancers: Mendelian randomization study
por: Yuan, Shuai, et al.
Publicado: (2022)

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
por: Martin, Susan, et al.
Publicado: (2022)

Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study
por: Howe, Laurence J, et al.
Publicado: (2022)

Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
por: Martin, Susan, et al.
Publicado: (2022)

Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study
por: Richardson, Tom G, et al.
Publicado: (2022)

IGF-1 and cardiometabolic diseases: a Mendelian randomisation study
por: Larsson, Susanna C., et al.
Publicado: (2020)

Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study
por: Yuan, Shuai, et al.
Publicado: (2022)

Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor
por: Liu, Hui, et al.
Publicado: (2021)

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study
por: Hughes, Amanda M, et al.
Publicado: (2022)

GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease: Mendelian Randomization and Polygenic Risk Score Analysis
por: Yu, Lili, et al.
Publicado: (2022)

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome
por: Cortez Cardoso Penha, Ricardo, et al.
Publicado: (2023)

A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots
por: Bejon, Philip, et al.
Publicado: (2014)

Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis
por: Chen, Jie, et al.
Publicado: (2022)

Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
por: Li, Wanxin, et al.
Publicado: (2023)

China’s human resources for maternal and child health: a national sampling survey
por: Ren, Zhenghong, et al.
Publicado: (2015)

An analysis of women’s and children’s health professional requirements in China in 2010 based on workload
por: Song, Peige, et al.
Publicado: (2014)

Systematic review of Mendelian randomization studies on risk of cancer
por: Markozannes, Georgios, et al.
Publicado: (2022)

Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis
por: Zhou, Xuan, et al.
Publicado: (2022)

Sleep duration and risk of overall and 22 site‐specific cancers: A Mendelian randomization study
por: Titova, Olga E., et al.
Publicado: (2020)

Whole grain consumption and risk of colorectal cancer: a population-based cohort of 60 000 women
por: Larsson, S C, et al.
Publicado: (2005)

A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk
por: Allen, N E, et al.
Publicado: (2005)

Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis
por: Li, Doudou, et al.
Publicado: (2022)

Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls
por: Chang, Yu-mei, et al.
Publicado: (2009)

The national and subnational prevalence and burden of age–related macular degeneration in China
por: Song, Peige, et al.
Publicado: (2017)

The national and subnational prevalence of cataract and cataract blindness in China: a systematic review and meta-analysis
por: Song, Peige, et al.
Publicado: (2018)

Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis
por: Song, Peige, et al.
Publicado: (2018)

Aspirin Use and Common Cancer Risk: A Meta-Analysis of Cohort Studies and Randomized Controlled Trials
por: Wang, Lijuan, et al.
Publicado: (2021)

Risk of psychiatric disorders among the surviving twins after a co-twin loss
por: Song, Huan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1qobp247cv6e6op2jnj6d67frr