A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there...

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Detalles Bibliográficos
Autores principales: Vides, Edmundo G, Adhikari, Ayan, Chiang, Claire Y, Lis, Pawel, Purlyte, Elena, Limouse, Charles, Shumate, Justin L, Spínola-Lasso, Elena, Dhekne, Herschel S, Alessi, Dario R, Pfeffer, Suzanne R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576273/
https://www.ncbi.nlm.nih.gov/pubmed/36149401
http://dx.doi.org/10.7554/eLife.79771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576273/
https://www.ncbi.nlm.nih.gov/pubmed/36149401
http://dx.doi.org/10.7554/eLife.79771

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