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Small molecule quercetin binds MALAT1 triplex and modulates its cellular function

The triple-helix structure at the 3′ end of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA, has been considered to be a target for modulating the oncogenic functions of MALAT1. This study examines the binding of quercetin—a known triplex binding molecule—to th...

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Detalles Bibliográficos
Autores principales: Rakheja, Isha, Ansari, Asgar Hussain, Ray, Arjun, Chandra Joshi, Dheeraj, Maiti, Souvik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576543/
https://www.ncbi.nlm.nih.gov/pubmed/36284512
http://dx.doi.org/10.1016/j.omtn.2022.09.016