Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses

Oncolytic adenovirus (oAd) elicits antitumor activity by preferential viral replication in cancer cells. However, poor systemic administrability or suboptimal intratumoral retainment of the virus remains a major challenge toward maximizing the antitumor activity of oAd in a clinical environment. To...

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Detalles Bibliográficos
Autores principales: Thambi, Thavasyappan, Hong, JinWoo, Yoon, A-Rum, Yun, Chae-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576595/
https://www.ncbi.nlm.nih.gov/pubmed/35444290
http://dx.doi.org/10.1038/s41417-022-00469-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576595/
https://www.ncbi.nlm.nih.gov/pubmed/35444290
http://dx.doi.org/10.1038/s41417-022-00469-y

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