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NrCAM secreted by endometrial stromal cells enhances the progestin sensitivity of endometrial cancer cells through epigenetic modulation of PRB

Progestin is one of the main hormone treatment regimens for early-stage estrogen receptor- and progesterone receptor (PR)-positive endometrial cancer (EC). However, the response rate of EC to progestins is unsatisfactory. Investigating the mechanisms related to progestin treatment could help improve...

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Detalles Bibliográficos
Autores principales: Cheng, Yali, Xie, Liying, Xu, Zhiying, Hao, Mengxin, Yang, Bingyi, Shan, Weiwei, Wang, Yiqin, Lv, Qiaoying, Chen, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576598/
https://www.ncbi.nlm.nih.gov/pubmed/35388173
http://dx.doi.org/10.1038/s41417-022-00467-0