Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis

Background: The emergence of chemoresistance in leukemia markedly impedes chemotherapeutic efficacy and dictates poor prognosis. Recent evidence has revealed that phosphatidylinositol 4 kinase-IIIα (PI4KA) plays a critical role in tumorigenesis. However, the molecular mechanisms of PI4KA-regulated c...

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Detalles Bibliográficos
Autores principales: Jiang, Xiuxing, Huang, Xiangtao, Zheng, Guoxun, Jia, Guanfei, Li, Zhiqiang, Ding, Xin, Lei, Ling, Yuan, Liang, Xu, Shuangnian, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576605/
https://www.ncbi.nlm.nih.gov/pubmed/36276647
http://dx.doi.org/10.7150/thno.76563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576605/
https://www.ncbi.nlm.nih.gov/pubmed/36276647
http://dx.doi.org/10.7150/thno.76563

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