Cargando…

Specificity of oligonucleotide gene therapy (OGT) agents

Oligonucleotide gene therapy (OGT) agents (e. g. antisense, deoxyribozymes, siRNA and CRISPR/Cas) are promising therapeutic tools. Despite extensive efforts, only few OGT drugs have been approved for clinical use. Besides the problem of efficient delivery to targeted cells, hybridization specificity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nedorezova, Daria D., Dubovichenko, Mikhail V., Belyaeva, Ekaterina P., Grigorieva, Ekaterina D., Peresadina, Arina V., Kolpashchikov, Dmitry M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576606/ https://www.ncbi.nlm.nih.gov/pubmed/36276652 http://dx.doi.org/10.7150/thno.77830

Ejemplares similares

OGT Protein Interaction Network (OGT-PIN): A Curated Database of Experimentally Identified Interaction Proteins of OGT
por: Ma, Junfeng, et al.
Publicado: (2021)

Visual Detection of Stem-Loop Primer Amplification (SPA) Products without Denaturation Using Peroxidase-like DNA Machines (PxDM)
por: Maltzeva, Yulia I., et al.
Publicado: (2023)

OGT Ohio graduation test mathematics
por: Brice, J, et al.
Publicado: (2012)

Towards sustainable diagnostics: replacing unstable H(2)O(2) by photoactive TiO(2) in testing systems for visible and tangible diagnostics for use by blind people
por: Lanchuk, Yulia V., et al.
Publicado: (2018)

OGT restrains the expansion of DNA damage signaling
por: Chen, Qiang, et al.
Publicado: (2016)

Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights
por: Miggiano, Riccardo, et al.
Publicado: (2017)

How the glycosyltransferase OGT catalyzes amide bond cleavage
por: Janetzko, John, et al.
Publicado: (2016)

Adipocyte OGT governs diet-induced hyperphagia and obesity
por: Li, Min-Dian, et al.
Publicado: (2018)

Activation by NarL at the Escherichia coli ogt promoter
por: Ruanto, Patcharawarin, et al.
Publicado: (2020)

Recognition and Sensing of Low-Epitope Targets via Ternary Complexes with Oligonucleotides and Synthetic Receptors
por: Yang, Kyung-Ae, et al.
Publicado: (2014)

Synthetic oligonucleotides as therapeutic agents.
por: Tidd, D. M.
Publicado: (1991)

Distinct OGT-Binding Sites Promote HCF-1 Cleavage
por: Bhuiyan, Tanja, et al.
Publicado: (2015)

Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors
por: Lim, Sungsu, et al.
Publicado: (2015)

Substrate Specificity Provides Insights into the Sugar Donor Recognition Mechanism of O-GlcNAc Transferase (OGT)
por: Ma, Xiaofeng, et al.
Publicado: (2013)

TET3- and OGT-Dependent Expression of Genes Involved in Epithelial-Mesenchymal Transition in Endometrial Cancer
por: Ciesielski, Piotr, et al.
Publicado: (2021)

OGT and FLAD1 Genes Had Significant Prognostic Roles in Progressive Pathogenesis in Prostate Cancer
por: Kim, Sung Han, et al.
Publicado: (2023)

An Elegant Biosensor Molecular Beacon Probe: Challenges and Recent Solutions
por: Kolpashchikov, Dmitry M.
Publicado: (2012)

Single Shot vs. Cocktail: A Comparison of Mono- and Combinative Application of miRNA-Targeted Mesyl Oligonucleotides for Efficient Antitumor Therapy
por: Gaponova, Svetlana, et al.
Publicado: (2022)

SIRT1 regulates O-GlcNAcylation of tau through OGT
por: Lu, Shu, et al.
Publicado: (2020)

Quantitative Proteomics Reveals that the OGT Interactome Is Remodeled in Response to Oxidative Stress
por: Martinez, Marissa, et al.
Publicado: (2021)

Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity
por: Wang, Qi, et al.
Publicado: (2022)

Operating Cooperatively (OC) Sensor for Highly Specific Recognition of Nucleic Acids
por: Cornett, Evan M., et al.
Publicado: (2013)

Thermonuclear processes of the universe
por: Borisovich Dubovichenko, Sergey
Publicado: (2012)

Tuberculosis in the Russian Federation: Prognosis and Epidemiological Models in a Situation After the COVID-19 Pandemic
por: Starshinova, Anna, et al.
Publicado: (2023)

Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer
por: Zhou, Fuxing, et al.
Publicado: (2018)

High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
por: Itkonen, Harri M, et al.
Publicado: (2019)

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila
por: Wong, Kenneth Kin Lam, et al.
Publicado: (2020)

Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening
por: Loi, Elena M., et al.
Publicado: (2022)

The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
por: Zuliani, Ilaria, et al.
Publicado: (2020)

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism
por: Zhang, Zengdi, et al.
Publicado: (2022)

Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML
por: Li, Hongjiao, et al.
Publicado: (2023)

Platelet-Derived Growth Factor Induces SASP-Associated Gene Expression in Human Multipotent Mesenchymal Stromal Cells but Does Not Promote Cell Senescence
por: Grigorieva, Olga, et al.
Publicado: (2021)

Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression
por: Olivier-Van Stichelen, S, et al.
Publicado: (2012)

Regulation of the Proteasome by AMPK in Endothelial Cells: The Role of O-GlcNAc Transferase (OGT)
por: Xu, Jian, et al.
Publicado: (2012)

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion
por: Seo, Hyeon Gyu, et al.
Publicado: (2020)

Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells
por: Esch, Nicholas, et al.
Publicado: (2020)

OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis
por: Li, Xiang, et al.
Publicado: (2023)

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy
por: Suvorov, Nikita, et al.
Publicado: (2021)

Enrichment of Viral Nucleic Acids by Solution Hybrid Selection with Genus Specific Oligonucleotides
por: Deviatkin, Andrei A., et al.
Publicado: (2017)

Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas.
por: Harris, L. C., et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_3hnt43eg5mfiksvgdj0qr5li7e