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A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR
Pathophysiology associated with Huntington’s disease (HD) has been studied extensively in various cell and animal models since the 1993 discovery of the mutant huntingtin (mHtt) with abnormally expanded polyglutamine (polyQ) tracts as the causative factor. However, the sequence of early pathophysiol...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576654/ https://www.ncbi.nlm.nih.gov/pubmed/36251090 http://dx.doi.org/10.1007/s00018-022-04587-6 |