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A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR

Pathophysiology associated with Huntington’s disease (HD) has been studied extensively in various cell and animal models since the 1993 discovery of the mutant huntingtin (mHtt) with abnormally expanded polyglutamine (polyQ) tracts as the causative factor. However, the sequence of early pathophysiol...

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Detalles Bibliográficos
Autores principales:	Hung, Chiu-Yueh, Zhu, Chuanshu, Kittur, Farooqahmed S., He, Maotao, Arning, Erland, Zhang, Jianhui, Johnson, Asia J., Jawa, Gurpreet S., Thomas, Michelle D., Ding, Tomas T., Xie, Jiahua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576654/ https://www.ncbi.nlm.nih.gov/pubmed/36251090 http://dx.doi.org/10.1007/s00018-022-04587-6

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