Mammalian N1-adenosine PARylation is a reversible DNA modification

Poly-ADP-ribosylation (PARylation) is regarded as a protein-specific modification. However, some PARPs were recently shown to modify DNA termini in vitro. Here, we use ultrasensitive mass spectrometry (LC-MS/MS), anti-PAR antibodies, and anti-PAR reagents to show that mammalian DNA is physiologicall...

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Detalles Bibliográficos
Autores principales: Musheev, Michael U., Schomacher, Lars, Basu, Amitava, Han, Dandan, Krebs, Laura, Scholz, Carola, Niehrs, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576699/
https://www.ncbi.nlm.nih.gov/pubmed/36253381
http://dx.doi.org/10.1038/s41467-022-33731-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576699/
https://www.ncbi.nlm.nih.gov/pubmed/36253381
http://dx.doi.org/10.1038/s41467-022-33731-w

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