Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability

In our previous study, we reported that sirtuin5 (SIRT5), a member of the NAD(+)-dependent class III histone deacetylase family, is highly expressed in colorectal cancer (CRC). Herein we show that SIRT5 knockdown impairs the production of ribose-5-phosphate, which is essential for nucleotide synthes...

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Detalles Bibliográficos
Autores principales: Wang, Hao-Lian, Chen, Yan, Wang, Yun-Qian, Tao, En-Wei, Tan, Juan, Liu, Qian-Qian, Li, Chun-Min, Tong, Xue-Mei, Gao, Qin-Yan, Hong, Jie, Chen, Ying-Xuan, Fang, Jing-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576705/
https://www.ncbi.nlm.nih.gov/pubmed/36253417
http://dx.doi.org/10.1038/s41467-022-33903-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576705/
https://www.ncbi.nlm.nih.gov/pubmed/36253417
http://dx.doi.org/10.1038/s41467-022-33903-8

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