HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design

BG24, a VRC01-class broadly neutralizing antibody (bNAb) against HIV-1 Env with relatively few somatic hypermutations (SHMs), represents a promising target for vaccine strategies to elicit CD4-binding site (CD4bs) bNAbs. To understand how SHMs correlate with BG24 neutralization of HIV-1, we report 4...

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Detalles Bibliográficos
Autores principales: Dam, Kim-Marie A., Barnes, Christopher O., Gristick, Harry B., Schoofs, Till, Gnanapragasam, Priyanthi N. P., Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576718/
https://www.ncbi.nlm.nih.gov/pubmed/36253376
http://dx.doi.org/10.1038/s41467-022-33860-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576718/
https://www.ncbi.nlm.nih.gov/pubmed/36253376
http://dx.doi.org/10.1038/s41467-022-33860-2

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