Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone

DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can “phenocopy” pathogenic mutations, but would not be identified using standard clinical sequencing, leading to missed opportunities for other patients to benefit...

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Detalles Bibliográficos
Autores principales: Bakhtiar, Hamza, Helzer, Kyle T., Park, Yeonhee, Chen, Yi, Rydzewski, Nicholas R., Bootsma, Matthew L., Shi, Yue, Harari, Paul M., Sharifi, Marina, Sjöström, Martin, Lang, Joshua M., Yu, Menggang, Zhao, Shuang G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576758/
https://www.ncbi.nlm.nih.gov/pubmed/36253482
http://dx.doi.org/10.1038/s41525-022-00328-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576758/
https://www.ncbi.nlm.nih.gov/pubmed/36253482
http://dx.doi.org/10.1038/s41525-022-00328-7

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