The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore gating is unknown. We studied purified human TRPA1 (hTRPA1) truncated proteins to gain insight into the temperature gating of hTRPA1. In pat...

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Detalles Bibliográficos
Autores principales: Moparthi, Lavanya, Sinica, Viktor, Moparthi, Vamsi K., Kreir, Mohamed, Vignane, Thibaut, Filipovic, Milos R., Vlachova, Viktorie, Zygmunt, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576766/
https://www.ncbi.nlm.nih.gov/pubmed/36253390
http://dx.doi.org/10.1038/s41467-022-33876-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576766/
https://www.ncbi.nlm.nih.gov/pubmed/36253390
http://dx.doi.org/10.1038/s41467-022-33876-8

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