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The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain
TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore gating is unknown. We studied purified human TRPA1 (hTRPA1) truncated proteins to gain insight into the temperature gating of hTRPA1. In pat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576766/ https://www.ncbi.nlm.nih.gov/pubmed/36253390 http://dx.doi.org/10.1038/s41467-022-33876-8 |