An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment

Protein phosphorylation is a major regulatory mechanism of cellular signalling. The c-JUN proto-oncoprotein is phosphorylated at four residues within its transactivation domain (TAD) by the JNK family kinases, but the functional significance of c-JUN multisite phosphorylation has remained elusive. H...

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Detalles Bibliográficos
Autores principales: Waudby, Christopher A., Alvarez-Teijeiro, Saul, Josue Ruiz, E., Suppinger, Simon, Pinotsis, Nikos, Brown, Paul R., Behrens, Axel, Christodoulou, John, Mylona, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576782/
https://www.ncbi.nlm.nih.gov/pubmed/36253406
http://dx.doi.org/10.1038/s41467-022-33866-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576782/
https://www.ncbi.nlm.nih.gov/pubmed/36253406
http://dx.doi.org/10.1038/s41467-022-33866-w

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