The vulnerability of radical SAM enzymes to oxidants and soft metals

Radical S-adenosylmethionine enzymes (RSEs) drive diverse biological processes by catalyzing chemically difficult reactions. Each of these enzymes uses a solvent-exposed [4Fe–4S] cluster to coordinate and cleave its SAM co-reactant. This cluster is destroyed during oxic handling, forcing investigato...

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Detalles Bibliográficos
Autores principales: Rohaun, Sanjay Kumar, Imlay, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576991/
https://www.ncbi.nlm.nih.gov/pubmed/36240621
http://dx.doi.org/10.1016/j.redox.2022.102495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576991/
https://www.ncbi.nlm.nih.gov/pubmed/36240621
http://dx.doi.org/10.1016/j.redox.2022.102495

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