Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration

We recently showed that the post-ischemic induction of matrix metalloproteinase-12 (MMP-12) in the brain degrades tight junction proteins, increases MMP-9 and TNFα expression, and contributes to the blood-brain barrier (BBB) disruption, apoptosis, demyelination, and infarct volume development. The o...

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Detalles Bibliográficos
Autores principales: Challa, Siva Reddy, Nalamolu, Koteswara Rao, Fornal, Casimir A., Wang, Billy C., Martin, Ryan C., Olson, Elsa A., Ujjainwala, Ammar L., Pinson, David M., Klopfenstein, Jeffrey D., Veeravalli, Krishna Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577328/
https://www.ncbi.nlm.nih.gov/pubmed/36267234
http://dx.doi.org/10.3389/fnins.2022.1012812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577328/
https://www.ncbi.nlm.nih.gov/pubmed/36267234
http://dx.doi.org/10.3389/fnins.2022.1012812

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