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Synthesis of the biologically important dideuterium-labelled adenosine triphosphate analogue ApppI(d(2))
The chemical synthesis of the dideuterium-labelled ATP analogue 1-adenosin-5’-yl-3-(3-methylbut-3-en-1,1-d(2)-1-ol) triphosphoric acid diester (ApppI(d(2))) is described. ApppI has been reported to be an important mevalonate pathway metabolite, induced by nitrogen-containing bisphosphonates used for...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Beilstein-Institut
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577381/ https://www.ncbi.nlm.nih.gov/pubmed/36300010 http://dx.doi.org/10.3762/bjoc.18.153 |