Podoplanin neutralization reduces thrombo-inflammation in experimental ischemic stroke by inhibiting interferon/caspase-1/GSDMD in microglia

BACKGROUND: Cerebral ischemia/reperfusion (I/R) injury involves the interaction between thrombosis and inflammatory pathways. The aim of this study was to explore the therapeutic effect of podoplanin neutralizing antibody (α-PDPN, clone 8.1.1) on I/R-induced thrombo-inflammation in a mouse model of...

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Detalles Bibliográficos
Autores principales: Qian, Shuang, Qian, Lei, Yang, Ye, Cui, Jie, Zhao, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577791/
https://www.ncbi.nlm.nih.gov/pubmed/36267799
http://dx.doi.org/10.21037/atm-22-3970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577791/
https://www.ncbi.nlm.nih.gov/pubmed/36267799
http://dx.doi.org/10.21037/atm-22-3970

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