Cargando…

Podoplanin neutralization reduces thrombo-inflammation in experimental ischemic stroke by inhibiting interferon/caspase-1/GSDMD in microglia

BACKGROUND: Cerebral ischemia/reperfusion (I/R) injury involves the interaction between thrombosis and inflammatory pathways. The aim of this study was to explore the therapeutic effect of podoplanin neutralizing antibody (α-PDPN, clone 8.1.1) on I/R-induced thrombo-inflammation in a mouse model of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qian, Shuang, Qian, Lei, Yang, Ye, Cui, Jie, Zhao, Yiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577791/ https://www.ncbi.nlm.nih.gov/pubmed/36267799 http://dx.doi.org/10.21037/atm-22-3970

Ejemplares similares

Thrombo-Inflammation and Immunological Response in Ischemic Stroke: Focusing on Platelet-Tregs Interaction
por: Cui, Jieqiong, et al.
Publicado: (2022)

Transcriptome sequencing analysis revealed the molecular mechanism of podoplanin neutralization inhibiting ischemia/reperfusion-induced microglial activation
por: Qian, Shuang, et al.
Publicado: (2022)

Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage
por: Gu, Lingui, et al.
Publicado: (2022)

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia
por: Wang, Kankai, et al.
Publicado: (2020)

Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke
por: Schuhmann, Michael K., et al.
Publicado: (2017)

Podoplanin in Inflammation and Cancer
por: Quintanilla, Miguel, et al.
Publicado: (2019)

CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke
por: Schuhmann, Michael K, et al.
Publicado: (2015)

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice
por: Kang, Lulu, et al.
Publicado: (2022)

The Role of Podoplanin in the Immune System and Inflammation
por: Zhang, Zhiyuan, et al.
Publicado: (2022)

Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy
por: Palacios-Acedo, Ana Luisa, et al.
Publicado: (2019)

Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation
por: Zaid, Younes, et al.
Publicado: (2022)

Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation
por: Kuijpers, Marijke J. E., et al.
Publicado: (2022)

Endothelial caveolin at the crossroad of thrombo-inflammation coupling
por: ElAli, Ayman
Publicado: (2022)

Editorial: Thrombo-inflammation in cardiovascular disease and health
por: Jung, Richard G., et al.
Publicado: (2023)

Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis
por: Cheng, Ziyu, et al.
Publicado: (2022)

CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke
por: Schuhmann, Michael K., et al.
Publicado: (2020)

Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
por: Xie, Wei, et al.
Publicado: (2023)

Mycobacterium tuberculosis PE_PGRS19 Induces Pyroptosis through a Non-Classical Caspase-11/GSDMD Pathway in Macrophages
por: Qian, Jianing, et al.
Publicado: (2022)

GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice
por: Yang, Xiaoxia, et al.
Publicado: (2023)

Tspan18 is a novel regulator of thrombo-inflammation
por: Gavin, Rebecca L., et al.
Publicado: (2020)

Platelet in thrombo-inflammation: Unraveling new therapeutic targets
por: Sharma, Swati, et al.
Publicado: (2022)

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
por: Heilig, Rosalie, et al.
Publicado: (2020)

Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells
por: Chen, Tuo, et al.
Publicado: (2022)

Tetracaine hydrochloride induces macrophage pyroptosis through caspase‑1/11‑GSDMD signaling pathways
por: Zhang, Ran, et al.
Publicado: (2023)

IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis
por: Dai, Qingqing, et al.
Publicado: (2020)

Role of Purinergic Signalling in Endothelial Dysfunction and Thrombo-Inflammation in Ischaemic Stroke and Cerebral Small Vessel Disease
por: Lee, Natasha Ting, et al.
Publicado: (2021)

NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression
por: Li, Shanshan, et al.
Publicado: (2021)

Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes
por: Wang, Gang, et al.
Publicado: (2022)

Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway
por: Cai, Qiaoting, et al.
Publicado: (2022)

Sexually dimorphic microglia and ischemic stroke
por: Kerr, Nadine, et al.
Publicado: (2019)

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
por: Rayes, Julie, et al.
Publicado: (2017)

Behçet's Syndrome as a Model of Thrombo-Inflammation: The Role of Neutrophils
por: Emmi, Giacomo, et al.
Publicado: (2019)

Thrombo-Inflammation: A Focus on NTPDase1/CD39
por: Morello, Silvana, et al.
Publicado: (2021)

Thrombo-Phlebitis in Pregnancy
por: Matthew, G. D.
Publicado: (1947)

Thrombo-Angiitis Obliterans
por: Chakravarti, D. C.
Publicado: (1935)

Thrombo-Angiitic Gangrene
Publicado: (1926)

Interleukin-35 exhibits protective effects in a rat model of hypoxic-ischemic encephalopathy through the inhibition of microglia-mediated inflammation
por: Liu, Guangliang, et al.
Publicado: (2022)

Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation
por: Lin, Shuang, et al.
Publicado: (2022)

Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke
por: Zhang, Wan, et al.
Publicado: (2020)

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review
por: Zeng, Jinsong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_97sv4nt7n0vfv1oi4ai8jff4er